Setting off on a road trip holds endless allure, and one of the greatest pleasures lies in experiencing the mesmerizing natural beauty that unfolds from behind the wheel. Within the southeastern region of the United States, the Carolinas emerge as an enticing destination where enchanting vistas, delectable cuisine, and an abundance of outdoor activities converge harmoniously. These neighboring states, intricately linked by scenic highways, welcome travelers to partake in an unforgettable journey. A road trip through the Carolinas offers a wonderful opportunity to explore diverse landscapes, rich history, and vibrant cities. Discover charming towns steeped in Southern hospitality, delve into the region's cultural heritage, and savor the flavors of local cuisine.

From thriving urban centers to coastal paradises to historical landmarks to serene mountain retreats, the Carolinas offer a tapestry of experiences waiting to be explored. Whether it's exploring the cobblestone streets of a historical town or relaxing on pristine beaches, each stop on this road trip will unveil unique treasures and create lasting memories. Get ready to hit the open road and embark on a remarkable adventure through North and South Carolina.

Please note that while the accommodations recommended in this article have been carefully selected based on extensive research, including user ratings of 8.2 or higher and favorable amenities, it is important for readers to independently verify all information and prices before making final decisions for their trip to the mentioned cities in North and South Carolina.

RELATED: 10 Things To Do In Charlotte: Complete Guide To North Carolina's Queen City

Charleston, South Carolina

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Colorful homes and a horse drawn carriage in the street
Photo by Leonel Heisenberg on Unsplash
Charming streets of Charleston, South Carolina 

Charleston, South Carolina, known for its rich history and Southern charm, captivates visitors with its timeless beauty and cultural heritage. From the iconic Rainbow Row to the historic plantations, the city showcases stunning architecture and cobblestone streets that transport you to another era. Explore the bustling downtown area or venture to nearby charming communities like Mount Pleasant, Summerville, and Folly Beach, each offering their own unique charm and attractions. With its vibrant culinary scene, picturesque waterfronts, and warm hospitality, Charleston invites travelers to immerse themselves in its captivating ambiance and create lasting memories in the heart of the Lowcountry.

Experience more than 300 years of history on a guided carriage tour of Charleston.

Tour: Charleston’s Old South Carriage Historic Horse & Carriage Tour

Cost: From $50.00 USD

Duration: 1 hour (approx)

Includes: 1-hour horse & carriage sightseeing tour of Charleston with a certified driver/guide

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Colorful homes and a horse drawn carriage in the street
Photo by Leonel Heisenberg on Unsplash
Charming streets of Charleston, South Carolina 
The Palmetto Hotel, Charleston
9.5 / 10
Amenities
Center City Location, Bar/Lounge, Free Wi-Fi, Valet parking
Price
$

Asheville, North Carolina

Biltmore Estates in Asheville North Carolina
Photo by Stephanie Klepacki on Unsplash
Biltmore Estates in Asheville North Carolina

Nestled in the Blue Ridge Mountains, Asheville, North Carolina, captivates visitors with its artistic atmosphere and natural splendor. Its diverse downtown area entices art lovers with galleries, shops, and lively music venues. Outdoor enthusiasts can explore the breathtaking beauty of the nearby Pisgah National Forest and Blue Ridge Parkway. A visit to the iconic Biltmore Estate, with its grand architecture and sprawling gardens, is a must. Asheville's vibrant food scene, craft breweries, and artistic vibe make it an alluring destination for travelers exploring the Carolinas. Nearby towns like Saluda offer a mountain oasis, while a trek to Tryon reveals a charming community and the childhood home of Nina Simone.

Ticket prices for the Biltmore vary by season; please review dates and prices on their website. Reservations are required every day for all guests for entry to Biltmore House. Please reserve house entry time online or over the phone when purchasing tickets.

Biltmore Estates in Asheville North Carolina
Photo by Stephanie Klepacki on Unsplash
Biltmore Estates in Asheville North Carolina
The Residences at Biltmore - Asheville
8.2 / 10
Hotel Chain

The Biltmore Company

Amenities
Outdoor pool, Fitness Center, Free Wi-fi, Free Parking
Price
$

Raleigh, North Carolina

Raleigh skyline serves as backdrop to flowers in Dorthea Dix Park | Raleigh, North Carolina
Photo by Reba Spike on Unsplash
Raleigh skyline serves as backdrop to flowers in Dorthea Dix Park | Raleigh, North Carolina

Raleigh, North Carolina, welcomes with its eclectic mix of history, modern culture, and natural beauty. Visitors will enjoy the thriving arts scene at the North Carolina Museum of Art, featuring exclusive exhibitions and installations. The rich heritage of the state can be explored at the North Carolina Museum of History, where interactive exhibits bring history to life. For book lovers of all ages, the James B. Hunt Library is a testament to Raleigh’s innovation, offering a truly immersive library experience. Family-friendly fun can be found at Pullen Park, with rides on the historic carousel and paddle boats. Neighboring Cary is a culinary paradise, boasting a plethora of new and delectable restaurants. To truly experience the essence of the region, venture beyond Raleigh and discover the vibrant Triangle area, encompassing Chapel Hill and Durham, each with its own unique charm and attractions.

Check out the best Raleigh has to offer on this two-hour pedal-powered pub crawl.

Tour: Trolley Pub Public Tour of Raleigh

Cost: From $45.00 USD

Duration: 2 hours (approx)

Includes: Two hours on the trolley pub, cooler, tours are BYOB

Raleigh skyline serves as backdrop to flowers in Dorthea Dix Park | Raleigh, North Carolina
Photo by Reba Spike on Unsplash
Raleigh skyline serves as backdrop to flowers in Dorthea Dix Park | Raleigh, North Carolina
The Casso, Raleigh, a Tribute Portfolio Hotel
9 / 10
Hotel Chain

Marriott

Amenities
Fitness center, Free Wi-fi, Bar/Lounge, Private parking, Restaurant
Price
$

Charlotte, North Carolina

Uptown Charlotte, North Carolina, at night
Photo by Wes Hicks on Unsplash
Uptown Charlotte, North Carolina, at night

Charlotte, North Carolina, embodies a vibrant spirit and diverse offerings that make it a standout destination. The city pulses with energy and creativity, evident in the eclectic NoDa district, known for its art galleries and live music venues. The Mint Museum showcases captivating art collections, while adrenaline lovers can satisfy their cravings at the U.S. National Whitewater Center. For racing enthusiasts, the NASCAR Hall of Fame is a thrilling tribute to the sport's legends. And let's not forget the exhilarating thrills of Carowinds amusement park. Charlotte's unique blend of culture, adventure, and entertainment creates a dynamic and memorable experience for all who visit.

Uptown Charlotte, North Carolina, at night
Photo by Wes Hicks on Unsplash
Uptown Charlotte, North Carolina, at night
Residence Inn by Marriott Charlotte City Center
8.9 / 10
Hotel Chain

Marriott

Amenities
Fitness center, Bar/Lounge, Restaurant, Free Wi-Fi
Price
$

Wilmington, North Carolina

Aerial view of Wrightsville Beach in Wilmington North Carolina
Photo by Samuel Cruz on Unsplash
Aerial view of Wrightsville Beach in Wilmington North Carolina

In the coastal gem of Wilmington, North Carolina, an array of attractions await road trippers. History enthusiasts can wander the decks of the World War II-era Battleship NORTH CAROLINA, a proud recipient of the esteemed title "Best Museum Ship" by USA TODAY 10 Best. For those seeking knowledge and discovery, the Cape Fear Museum of History and Science offers a captivating experience. Meanwhile, the Wilmington Railroad Museum delights both young and old with model trains and a 100-year-old steam locomotive. Thrills and spills can be found at the Jungle Rapids Family Fun Park, hailed as the "Best Water Park in Eastern North Carolina." And, of course, there are the beaches that beckon with their beauty and charm - Carolina Beach, Kure Beach, and Wrightsville Beach - offering tranquil escapes and sun-soaked adventures.

Aerial view of Wrightsville Beach in Wilmington North Carolina
Photo by Samuel Cruz on Unsplash
Aerial view of Wrightsville Beach in Wilmington North Carolina
SpringHill Suites by Marriott Wilmington Mayfaire
8.8 / 10
Hotel Chain

Marriott

Amenities
Outdoor pool, Fitness center, Free parking, Bar/Lounge
Price
$

Greenville, South Carolina

A small waterfall near downtown Greenville South Carolina
Photo by Levi Meir Clancy on Unsplash
A small waterfall near downtown Greenville South Carolina

In Greenville, South Carolina, adventure and delectable flavors await around every corner. The Gorge Zipline Canopy Tour offers exhilarating treetop experiences, while Falls Park on the Reedy, with its iconic Liberty Bridge, mesmerizes visitors with breathtaking views. Green River Adventures beckons thrill-seekers with whitewater kayaking, swimming hole hikes, and daring Waterfall Rappel adventures. But it's not just about adrenaline; Greenville's food scene has garnered prestigious acclaim. Zagat hails it as the "#1 Under-the-Radar Southern Food Destination," Esquire names it the "Next Big Food City of the South," and Southern Living celebrates it as one of "The South's Tastiest Towns." Discover the electric spark of Greenville, a city that captivates hearts and palates alike.

A small waterfall near downtown Greenville South Carolina
Photo by Levi Meir Clancy on Unsplash
A small waterfall near downtown Greenville South Carolina
The Westin Poinsett, Greenville
9 / 10
Hotel Chain

Marriott

Amenities
Fitness center, Bar/Lounge, Valet Parking, Restaurant, Free Wi-fi
Price
$

Hilton Head Island, South Carolina

Aerial view of Hilton Head island in South Carolina
Deposit Photos
Aerial view of Hilton Head island in South Carolina

Hilton Head Island, South Carolina, is a beautiful coastal paradise with world-class golf courses and a vibrant cultural heritage. The island's pristine beaches beckon sun-seekers to unwind on soft sand and bask in the tranquil ocean breeze. Golf enthusiasts will find their paradise on the island's championship courses, where lush fairways and stunning views create an unforgettable experience. For a deeper understanding of the island's history, the Gullah Museum of Hilton Head Island provides a nuanced exploration of the vibrant Gullah culture, preserving their traditions and stories. Hilton Head Island invites visitors to immerse themselves in its coastal charm, indulge in outdoor activities, and discover the rich tapestry of its cultural heritage.

Exterior, Courtyard by Marriott Hilton Head Island
Photo Courtesy of Marriott
Exterior, Courtyard by Marriott Hilton Head Island
Courtyard by Marriott Hilton Head Island
8.7 / 10
Hotel Chain

Marriott

Amenities
Outdoor pool, Fitness center, Restaurant, Free Wi-Fi
Price
$$

RELATED: 10 Things To Do On Hilton Head Island: Complete Guide To South Carolina's Charming Coastal Getaway

Columbia, South Carolina

Flamingos hanging out at the Riverbanks Zoo and Garden in Columbia South Carolina

Photo by Karolina Bobek on Unsplash
Flamingos hanging out at the Riverbanks Zoo and Garden in Columbia South Carolina

Columbia, the capital city of South Carolina, welcomes visitors to delve into its local history and cultural offerings. From the South Carolina State House to the Riverbanks Zoo and Garden, there's something for everyone. Located on the banks of the Congaree River, Columbia offers outdoor activities like kayaking and scenic trails. Food enthusiasts will delight in the vibrant culinary scene, including the annual Columbia Food and Wine Festival. Sports fans can cheer on the Columbia Fireflies, while those seeking unique flavors can indulge in the city's array of restaurants and breweries. Columbia is a city of warmth, heritage, and delectable pimento cheese, inviting visitors to explore its charm.

Flamingos hanging out at the Riverbanks Zoo and Garden in Columbia South Carolina

Photo by Karolina Bobek on Unsplash
Flamingos hanging out at the Riverbanks Zoo and Garden in Columbia South Carolina
Cambria Hotel Columbia Downtown, The Vista
9.1 / 10
Hotel Chain

Choice Hotels

Amenities
Fitness center, Valet Parking, Bar/Lounge, Restaurant
Price
$

Spartanburg, South Carolina

Cars parked along a street in Spartanburg South Carolina

Photo by Zac Gudakov on Unsplash
Cars parked along a street in Spartanburg South Carolina

Spartanburg, South Carolina, is a hidden gem brimming with charm and an array of exciting attractions. The city's dining scene is a true delight, offering menus bursting with farm-to-fork options that cater to diverse palates. Outdoor enthusiasts will find solace in Croft State Park, boasting over 20 miles of scenic biking and hiking trails, along with a playground perfect for picnicking and camping. For those seeking adventure, the BMW Performance Center provides thrilling driving experiences. Meanwhile, The Rail Yard Community Park is a vibrant hub, home to the Panthers Play 60, where children can embrace active play. Spartanburg truly offers a nuanced blend of natural beauty and community spirit.

Cars parked along a street in Spartanburg South Carolina

Photo by Zac Gudakov on Unsplash
Cars parked along a street in Spartanburg South Carolina
Four Points by Sheraton Spartanburg
8.6 / 10
Hotel Chain

Marriott

Amenities
Indoor pool, Free parking, Fitness center, Bar/Lounge
Price
$

RELATED: 10 Truly Underrated Towns In North Carolina That Deserve To Be Explored

Greensboro, North Carolina

Aerial view of Lebauer Park in Greensboro North Carolina
Photo by Samuel Cruz on Unsplash
Aerial view of Lebauer Park in Greensboro North Carolina

In Greensboro, North Carolina, history, culture, and natural beauty intertwine to offer an enriching experience. Travelers can delve into the city's significant Civil Rights history by exploring the International Civil Rights Center & Museum, where the powerful stories of the movement come to life. For a touch of wonder, the Greensboro Science Center captivates with its fascinating exhibits, and the Greensboro Arboretum offers a tranquil stop with its serene botanical gardens. History buffs will enjoy the Guilford Courthouse National Military Park, and outdoor enthusiasts can relish in the city's abundant parks and trails. The diverse culinary scene, from tantalizing barbecue to globally inspired flavors, promises a delectable journey. Consider venturing to neighboring High Point and Winston-Salem for even more vibrant and captivating experiences.

Aerial view of Lebauer Park in Greensboro North Carolina
Photo by Samuel Cruz on Unsplash
Aerial view of Lebauer Park in Greensboro North Carolina
Marriott Greensboro Downtown
8.2 / 10
Hotel Chain

Marriott

Amenities
Fitness center, Bar/Lounge, Free Wi-fi, Restaurant
Price
$

Who decided to split North and South Carolina?North and South Carolina's “split,” decreed from the British Crown, was complete by 1729.